Karyopharm Therapeutics (NASDAQ: KPTI ) surging incessantly throughout the day, and ending higher by 93.5% after announcing phase 1 data of its investigational drug selinexor in combination with low-dose dexamethasone in heavily pretreated multiple myeloma patients. Initial results of its study demonstrated that the overall response rate was 50%, with a clinical benefit rate of 75%. What's incredible about these results is that the average patient had received 5.5 prior lines of therapy. Also, adverse events associated with the combo therapy were generally low-grade in nature, meaning it was well-tolerated.
Simply put, most patients often don't have much of an overall response in the later stages of multiple myeloma, so Karyopharm's impressive response rate is turning some heads. Keep in mind, though, that we're only talking about a handful of patients here, and we may want to reserve judgment until we have a bigger patient pool to study.
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