==MBX Biosciences (MBX) : Promising New Thyroid Disease Treatment

 

MBX Biosciences (MBX) is testing a weekly shot called canvuparatide in patients with chronic hypoparathyroidism, a condition in which the body doesn't produce enough parathyroid hormone. Parathyroid hormone is necessary for regulating the levels of calcium in the body.

In the study, 63% of canvuparatide recipients made it 12 weeks without needing parathyroid hormone, or PRN, rescue therapy. This means their calcium levels remained at normal levels. In the open-label extension study — in which all patients knowingly receive the drug — 79% of patients were responders at six months.

Based on the results, MBX Biosciences is now planning a Phase 3 study for 2026.

StubHub to price IPO at $23.50, valuing company at $8.6 billion

StubHub is pricing its IPO at $23.50 after last week providing a range of $22 to $25.

• The online ticket platform delayed its debut twice, most recently due to market volatility following President Donald Trump’s sweeping tariffs announced in April.

• The IPO market has been picking up steam of late after a multiyear drought.
• StubHub plans to sell 34 million shares, priced at $23.50 a share, valuing the company at $8.6 billion.
• Despite robust IPO demand, StubHub faces challenges, including competition and slowing sales growth, with an 88% CEO voting stake.
• The ticket business is highly competitive, with StubHub going up against Ticketmaster owner Live Nation (LYV) and other resellers such as Vivid Seats (SEAT) and privately held SeatGeek. Vivid Seats has plunged more than 80% this year. The company cited “pressure on consumer spending coupled with continued competitive intensity” in its most recent earnings report.

The pricing comes at the midpoint of the expected range that the company gave last week. At $23.50, the pricing gives StubHub a valuation of $8.6 billion.

StubHub confirmed the IPO pricing in a release late Tuesday. The company said its shares are expected to begin trading on the New York Stock Exchange on Wednesday under the symbol “STUB.”

The San Francisco-based company was co-founded by Eric Baker in 2000, and was acquired by eBay for $310 million seven years later. Baker reacquired StubHub in 2020 for roughly $4 billion through his new company Viagogo, which operates a ticket marketplace in Europe.

At the top of the pricing range StubHub offered last week, the company would have been valued at $9.2 billion. StubHub had sought a $16.5 billion valuation before it began the IPO process. 

StubHub said in its updated prospectus that first-quarter revenue increased 10% from a year earlier to $397.6 million. Operating income came in at $26.8 million for the period.

The company’s net loss widened to $35.9 million from $29.7 million a year ago.

==Lendbuzz (LBZZ) has filed a registration statement for proposed IPO

• Lendbuzz intends to list its common stock on The Nasdaq Global Select Market under the ticker symbol "LBZZ."
• Goldman Sachs & Co. LLC, J.P. Morgan, RBC Capital Markets and Mizuho will act as lead book-running managers for the proposed offering. TD Securities, Citizens Capital Markets, Keefe, Bruyette & Woods, a Stifel Company, and Needham & Company will act as passive bookrunners for the proposed offering.